“Allegro is excited to share our ex-U.S. proof-of-concept data of ALG-1007 for dry eye disease,” said Vicken Karageozian, M.D., President and CEO of Allegro Ophthalmics. “These early results suggest that ALG-1007 improves the signs and symptoms of dry eye, a disease that affects millions of people globally, with symptoms that include scratchy, stinging or burning sensations, and pain or redness in the eye.

ALG-1007 bolsters Allegro’s existing anti-integrin portfolio, which includes risuteganib (Luminate ®), currently being developed for diabetic macular edema (DME) and intermediate dry age-related macular degeneration (intermediate dry AMD).

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It is currently in Phase 2 development outside the ALG-1007 bolsters Allegro’s existing anti-integrin portfolio, which includes risuteganib (Luminate ® ), currently being developed for diabetic macular edema (DME) and intermediate dry age Allegro Ophthalmics announced positive results of an ex-US proof-of-concept clinical trial of the new investigational ALG-1007 topical drop drug candidate in patients with dry eye disease (DED). The results were presented by Eric D. Donnenfeld, MD, last week at the 2019 American Society of Cataract and Refractive Surgery and American Society of Ophthalmic Administrators (ASCRS•ASOA) Annual Meeting in San Diego.[1] ALG-1007 has successfully completed an ex-U.S. proof-of-concept study in humans, and is currently being evaluated in a larger ex-U.S. Phase 2 study. For more information, visit www.allegroeye.com .

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“Allegro is continuously exploring new ways to apply our anti-integrin portfolio to help improve patients’ vision, and ALG-1007 represents our first exploratory drug for the potential treatment of dry eye, a disease that adversely affects millions of Americans.” The corporate and scientific presentations are scheduled as follows:

ALG 1007 inhibits the leucocyte Other ophthalmology assets of Allegro include ALG-1007, a topical integrin regulator under investigation for the treatment of dry eye disease. The views and opinions expressed herein are the views ALG-1007 bolsters Allegro’s existing anti-integrin portfolio, which includes risuteganib (Luminate ®), currently being developed for diabetic macular edema (DME) and intermediate dry age-related macular degeneration (intermediate dry AMD). Other ophthalmology assets of Allegro include ALG-1007, a topical integrin regulator under investigation for the treatment of dry eye disease. It is currently in Phase 2 development outside the Allegro has a clear path forward and is gearing up for a larger US Phase 2b/3 trial in dry AMD in 1H 2020 ALG-1007 for topical use in dry eye disease demonstrated an improvement in both signs and symptoms of DED Allegro has initiated a second larger exploratory ex-US DED study looking at higher doses in a vehicle-controlled study Pipeline Allegro seeks to uncover groundbreaking treatments for eye care patients who have limited or no options, or who inadequately respond to existing therapies. more… Therapeutic Areas Allegro focuses on ocular diseases with unmet needs such as intermediate dry AMD, DME and dry eye disease. ALG 1007, a peptide integrin inhibitor is being developed by Allegro Ophthalmics for the treatment of dry eye disease (DED). ALG 1007 inhibits the leucocyte Allegro Ophthalmics announced positive results of an ex-US proof-of-concept clinical trial of the new investigational ALG-1007 topical drop drug candidate in patients with dry eye disease (DED).

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Expanding its anti-integrin portfolio, Allegro has developed ALG-1007, an anti-integrin drug candidate for topical use in DED. ALG-1007 has successfully completed an ex-U.S. proof-of-concept study in humans, and is currently being evaluated in a larger ex-U.S. Phase 2 study. Expanding its anti-integrin portfolio, Allegro has developed ALG-1007, an anti-integrin drug candidate for topical use in dry eye disease.

The candidate is in Phase II development outside the US. 2019-05-14 · Allegro Ophthalmics, LLC, a privately held biopharmaceutical company focused on the development of novel anti-integrin therapies for the treatment of ocular diseases, today announced positive results of an ex-U.S. proof-of-concept clinical trial of the new investigational ALG-1007 topical drop drug candidate in patients with dry eye disease (DED). “Allegro is excited to share our ex-U.S.
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Allegro Ophthalmics announced the expansion of the company’s anti-integrin portfolio with the new topical dry eye disease drug candidate ALG-1007. ALG-1007 bolsters Allegro’s existing anti-integrin portfolio, which includes risuteganib (Luminate), currently being developed for diabetic macular edema (DME) and intermediate dry age-related

A second and larger ex-U.S. Phase 2 clinical trial was successfully Expanding its anti-integrin portfolio, Allegro has developed ALG-1007, an anti-integrin drug candidate for topical use in DED. ALG-1007 has successfully completed an ex-U.S. proof-of-concept study in humans, and is currently being evaluated in a larger ex-U.S. Phase 2 study.

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On Thursday, May 2, Allegro’s President and CEO Vicken Karageozian, M.D., will provide an overview on the company’s vision moving forward into other ocular indications at the Ophthalmology Innovation Summit (OIS). Then on Monday, May 6, Eric D. Donnenfeld, M.D., will present full study results of the ALG-1007 ex-U.S. proof-of-concept clinical trial for DED at ASCRS•ASOA. CHICAGO, IL — October 16, 2014 — Allegro Ophthalmics, LLC, dedicated to establishing integrin peptide therapy as the next-generation pharmaceutical category for the treatment of vitreoretinal diseases, today announced that it is enrolling patients in a Phase 2 trial that will evaluate the safety and efficacy of Luminate®, previously known as ALG-1001, in patients with diabetic macular edema (DME). ALG-1007.

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